Synergistic Effect of Combined Hyperthermia and a Nitrosourea in Treatment of a Murine Ependymoblastoma1
نویسندگان
چکیده
The effectiveness of heat therapy in combination with i -(2chboroethyl)-3-cycbohexyl-1-nitrosourea on a murine ependy mobbastomawas investigated. Based on survival time and the number of survivors, whole-body hyperthermia (40°)increased the therapeutic effectiveness of 1-(2-chboroethyb)-3-cycbohexyl 1-nitrosourea. Heat alone did not modify the course of the tumor. Microscopic evidence of accelerated tumor destruction in hyperthermic mice was apparent within 24 hr of drug admin istration. A temporary drop in animal weight was observed with hyperthermia at the higher dose levels of drug. Mechanisms which may be involved in this synergism are discussed.
منابع مشابه
Synergistic effect of combined hyperthermia and a nitrosourea in treatment of a murine ependymoblastoma.
The effectiveness of heat therapy in combination with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea on a murine ependymoblastoma was investigated. Based on survival time and the number of survivors, whole-body hyperthermia (40 degrees) increased the therapeutic effectiveness of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. Heat alone did not modify the course of the tumor. Microscopic evidence o...
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